"IV Drug Use Compromises Integrity of Cell Membranes Prior to HIV
Infection"
Reuters (02/14/96)
Researchers in Switzerland have reported that intravenous drug
use "compromises the biochemical and structural integrity of the
membrane surface" of blood cells even before HIV infection. The
researchers studied the blood cells of 101 injection drug users,
including 91 who were HIV-positive, as well as the blood of a
control group HIV-negative IV drug users. The scientists found
that both groups had abnormal surface enzyme kinetics in their
peripheral blood mononuclear cells.
31
Dec
Evidence for co-factors/"rethinking"
In <4g5d9l$…@maureen.teleport.com> BKLBKL…@aol.com (BKL) writes:
>"IV Drug Use Compromises Integrity of Cell Membranes Prior to HIV
>Infection"
>Reuters (02/14/96)
> Researchers in Switzerland have reported that intravenous drug
>use "compromises the biochemical and structural integrity of the
>membrane surface" of blood cells even before HIV infection. The
>researchers studied the blood cells of 101 injection drug users,
>including 91 who were HIV-positive, as well as the blood of a
>control group HIV-negative IV drug users. The scientists found
>that both groups had abnormal surface enzyme kinetics in their
>peripheral blood mononuclear cells.
There is epidemiologic evidence that IV drug use (though not other
kinds of drug use) is a cofactor for development of AIDS in HIV
positive people. There is no evidence that HIV-negative people are
immunocompromised in an AIDS-type fashion by IV drug use, and
considerable evidence against the notion.
Steve Harris, M.D.
Steven B. Harris/Virginia George wrote:
- Hide quoted text — Show quoted text -
> In <4g5d9l$…@maureen.teleport.com> BKLBKL…@aol.com (BKL) writes:
> >"IV Drug Use Compromises Integrity of Cell Membranes Prior to HIV
> >Infection"
> >Reuters (02/14/96)
> > Researchers in Switzerland have reported that intravenous drug
> >use "compromises the biochemical and structural integrity of the
> >membrane surface" of blood cells even before HIV infection. The
> >researchers studied the blood cells of 101 injection drug users,
> >including 91 who were HIV-positive, as well as the blood of a
> >control group HIV-negative IV drug users. The scientists found
> >that both groups had abnormal surface enzyme kinetics in their
> >peripheral blood mononuclear cells.
> There is epidemiologic evidence that IV drug use (though not other
> kinds of drug use) is a cofactor for development of AIDS in HIV
> positive people. There is no evidence that HIV-negative people are
> immunocompromised in an AIDS-type fashion by IV drug use, and
> considerable evidence against the notion.
> Steve Harris, M.D.
Steve,
I’d be curious to know more about studies that suggest that injection
drug use speeds disease progression in HIV+ folks.
Most of the literature I have read suggests otherwise. See, for example
Galli M et ak. No evidence for a role of continuous intravenous drug
injection in accelerating disease progression in HIV-1 positive subjects.
IntConf AIDS; 7(2):67 (abstract THC.48), June 16-21, 1991.
In <31366217.6…@nih.gov> Greg Folkers <folk…@nih.gov> writes:
- Hide quoted text — Show quoted text -
>Steven B. Harris/Virginia George wrote:
>> In <4g5d9l$…@maureen.teleport.com> BKLBKL…@aol.com (BKL) writes:
>> >"IV Drug Use Compromises Integrity of Cell Membranes Prior to HIV
>> >Infection"
>> >Reuters (02/14/96)
>> > Researchers in Switzerland have reported that intravenous drug
>> >use "compromises the biochemical and structural integrity of the
>> >membrane surface" of blood cells even before HIV infection. The
>> >researchers studied the blood cells of 101 injection drug users,
>> >including 91 who were HIV-positive, as well as the blood of a
>> >control group HIV-negative IV drug users. The scientists found
>> >that both groups had abnormal surface enzyme kinetics in their
>> >peripheral blood mononuclear cells.
>> There is epidemiologic evidence that IV drug use (though not other
>> kinds of drug use) is a cofactor for development of AIDS in HIV
>> positive people. There is no evidence that HIV-negative people are
>> immunocompromised in an AIDS-type fashion by IV drug use, and
>> considerable evidence against the notion.
>> Steve Harris, M.D.
>Steve,
>I’d be curious to know more about studies that suggest that injection
>drug use speeds disease progression in HIV+ folks.
Two suggestive references are my 57 and 58: AIDS: 8:339-386, 1994, and
Br. Med. J. 301:1362-5,1990.
>Most of the literature I have read suggests otherwise. See, for
example
>Galli M et ak. No evidence for a role of continuous intravenous drug
>injection in accelerating disease progression in HIV-1 positive
subjects.
>IntConf AIDS; 7(2):67 (abstract THC.48), June 16-21, 1991.
I dunno– I think the issue is still controversial. Have any other
references for this point of view?
Steve
- Hide quoted text — Show quoted text -
> >> There is epidemiologic evidence that IV drug use (though not other
> >> kinds of drug use) is a cofactor for development of AIDS in HIV
> >> positive people. There is no evidence that HIV-negative people are
> >> immunocompromised in an AIDS-type fashion by IV drug use, and
> >> considerable evidence against the notion.
> >> Steve Harris, M.D.
> >Steve,
> >I’d be curious to know more about studies that suggest that injection
> >drug use speeds disease progression in HIV+ folks.
> Two suggestive references are my 57 and 58: AIDS: 8:339-386, 1994, and
> Br. Med. J. 301:1362-5,1990.
> >Most of the literature I have read suggests otherwise. See, for
> example
> >Galli M et ak. No evidence for a role of continuous intravenous drug
> >injection in accelerating disease progression in HIV-1 positive
> subjects.
> >IntConf AIDS; 7(2):67 (abstract THC.48), June 16-21, 1991.
> I dunno– I think the issue is still controversial. Have any other
> references for this point of view?
> Steve
Steve, here are some papers I have in my file that suggest that
injection drug use does not hasten CD4+ T cell loss, and/or that
injection drug users have rates of disease progression similar to other
HIV-infected people. I concur that the jury is probably still out on the
issue.
Of course injection drug use has many other deleterious effects,
including a dimunition of NK cell activity, and should be avoided. But
to echo your post, there is NO EVIDENCE that injection drug use causes,
in HIV-seronegative people — the specific immunologic profile of AIDS —
progressive and persistent reductions in CD4+ T cells and profound
deficits in cell-mediated immunity. Progressive and persistent are the
operative words here.
GREG
Galli, Clin Immunol Immunopathol 1989; 50: S166-76
Margolick, JAMA 1992; 267(12_1631-66
Margolick, Arch Intern Med 1994; 154(8):869-75
Montella, JAMA 1992; 268(18):2516-7.
Alcabes, Ann Epidem 1994; 4(1):17-26
Alcabes, Am J Epidem 1993; 137(9):989-1000
Italian Serovcenversion Study AIDS 1992; 6(4):421-26.
Galai J Acquir Immune Def Syndr 1995; 8:66-74
Selwyn N Engl J Med 1992; 327(4):1697-7-3.
Munoz, J Acquir Immune Def Syndr 1992; 5(7):694-700
MAP Workshop. Stat Med 1993; 12(22):2065-85
Pezzoti J Acquir Immune Defic Syndr 1992; 5(7):745-7.
Rezza Eur J Epidem 1990; 6(1):99-101.
You will study your self into an early grave with all this useless
writing. AIDS has been and is curable with a few changes in
lifestyle, namely no drugs and a raw food diet and plenty of
exercise. There is an obsession with "studies" that are totally
irrelevant to anything and all that does is cover up the truth.
The medical community is obsessed with selling drugs. Drugs and
money. No sickness, no work. If anyone wants to cure themselves
of AID OR ANYTHING ELSE STOP THE CAUSES. Remember cause and
effect — there are no pill cures.
Hank
You will study your self into an early grave with all this useless
writing. AIDS has been and is curable with a few changes in
lifestyle, namely no drugs and a raw food diet and plenty of
exercise. There is an obsession with "studies" that are totally
irrelevant to anything and all that does is cover up the truth.
The medical community is obsessed with selling drugs. Drugs and
money. No sickness, no work. If anyone wants to cure themselves
of AID OR ANYTHING ELSE STOP THE CAUSES. Remember cause and
effect — there are no pill cures.
Hank